Understanding how medical weight loss works puts you back in the driver’s seat of your weight issues.
The main action of semaglutide is to act as a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the effects of the naturally occurring hormone GLP-1 in the body. With its ability to boost insulin secretion and reduce glucagon release, GLP-1 helps regulate blood sugar levels. It also increases feelings of fullness and satisfaction, helping to reduce food consumption and aid in weight loss.
Semaglutide is highly beneficial for weight loss in clinical trials. In a randomized, double-masked study of over 1,900 adults with obesity, semaglutide injections once a week for 68 weeks resulted in an average loss of 15% of body weight, compared to 2.4% for placebo injections. Semaglutide was also associated with improved blood pressure, cholesterol levels, and quality of life.
While semaglutide is highly effective for weight loss, it is not a miracle cure. There is no need to replace healthy eating and consistent physical activity as part of a healthy lifestyle. However, it can be a valuable tool for individuals struggling to achieve significant weight loss, particularly those with obesity-related comorbidities.
Like any medication, semaglutide is not without potential side effects, which can consist of nausea, diarrhea, and vomiting. However, these are generally mild and tend to subside over time.
Tirzepatide has a similar function, though it differs from semaglutide in that it’s the first and only obesity/type 2 diabetes treatment for adults that activates both GIP and GLP-1 hormone receptors. It also mimics the action of glucagon-like peptide-1 (GLP-1), a naturally occurring hormone in the body. GLP-1 is released from the gut in response to food intake.
Tirzepatide regulates blood sugar levels by increasing insulin secretion from the pancreas and reducing the production of glucagon. It can provide the client with a feeling of fullness/satiety to help with urge control, and it can slow down the emptying of the stomach—which helps control the rise in blood sugar levels after meals. This dual action on both blood sugar and weight makes tirzepatide a good option for clients with type 2 diabetes who can benefit from both outcomes.
It’s important to discuss these options with your Lexington Prime MD or PA-C, and so is your willingness to change your lifestyle to support your goals. Learning, understanding, and turning that information into action will help you gain control over obesity, and put you back on the road to better health!